Choosing a Weapon Loadout
Mine Cells weapons fall into melee, ranged, and shield categories:
- Melee: Assassin's Dagger (backstab bonus),
Balanced Blade (reliable combo), 
Broadsword (slow, heavy), 
Blood Sword (bleed), 
Cursed Sword (high damage, risky), 
Crowbar, 
Cudgel. - Ranged:
Bow and Endless Quiver — infinite ammo, ideal for kiting bosses. - Shields:
Assault Shield (parry projectiles), 
Bloodthirsty Shield (heals on kill), and others.
Carry one melee, one ranged, and one shield. Shields are not optional in boss fights — parrying is how you create damage windows.
Crafting Materials to Collect
Key materials include 
Cell-infused Steel, 
Buzzcutter Fang, Conjunctivius's Tentacle, 
Arcane Goo, 
Blood Bottle, and 
Ancient Septite Bricks (plus their slab, stair, and wall variants for building). 
Bloomrock and its brick variants are decorative blocks from the dimension.
Alchemy and Vials
Use 
Alchemical Equipment and 
Alchemical Vials to brew consumables. Gather 
Ancient Sewage (bucket form too) and Arcane Goo as reagents. Brew healing and buff vials before boss attempts — they stack with food and make Elite fights far more survivable.